Welcome to the step-by-step guide that explains how to test for and manage MTHFR mutations.
Testing for MTHFR Mutations...
Want to know if you have MTHFR mutations? Follow these three steps:
Step 1: Order a 23andMe DNA Test
Your first step is to purchase an at-home DNA test from 23andMe. The test costs $199, and in addition to providing data for MTHFR analysis, you will receive reports about your health and ancestry. The test is easy to do—you just spit in the collection tube that they send you and then mail it back.
Step 2: Genetic Genie Methylation Analysis
After you get your 23andMe results, go to Genetic Genie for free methylation analysis. Your methylation report will include your MTHFR results. This service is free but donations are encouraged.
Step 3: Interpreting Your Results
Your methylation report from Genetic Genie will show if you are homozygous (+/+), heterozygous (+/-), or do not have MTHFR mutations (-/-). A homozygous mutation means you have two copies of the mutation and puts you at highest risk for negative health effects. A heterozygous mutation means you have one copy and puts you at moderate risk. Having more than one type of MTHFR mutation will also increase your risk.
Managing MTHFR Mutations...
Want to know what to do about MTHFR mutations? Follow these three steps:
Step 1: Methylfolate & Methyl-B12
Methylfolate and methyl-B12 are the biologically active forms of folate and vitamin B12. If you have any of the MTHFR mutations, you require increased amounts of these vitamins and cannot readily utilize synthetic forms (folic acid and cyanocobalamin) found in many foods and supplements. You should consider taking methylfolate and methyl-B12 supplements instead.
Step 2: Epigenetics & Lifestyle
Epigenetics refers to how our lifestyle influences genetic expression. This means you can reduce the expression of MTHFR mutations by following a healthy lifestyle— namely, one that limits inflammation. This includes eating a healthy diet, exercising in moderation (but not excessively), and using relaxation techniques such as meditation or yoga to minimize stress. Consider reading the short ebook Cold Dark Keto: Winter Simulation for Optimal Health by Steven Thomas, which explains critical aspects of a healthy lifestyle most people are missing. Mark Sisson’s books The Primal Blueprint and The Primal Connection are also useful resources for learning what a healthy lifestyle should look like.
Step 3: Epigenetics & Supplementation
In addition to healthy lifestyle practices, you can further control the epigenetics of MTHFR mutations with a supplementation regimen that keeps inflammation in check. The powerhouse in this category is ubiquinol, which is the reduced form of Coenzyme Q10 and acts as a potent antioxidant in the body. Other anti-inflammatory supplements to consider include curcumin and resveratrol. Additionally, many people are deficient in vitamin D, vitamin K2, and DHA/EPA, and require supplementation of these nutrients to achieve optimal epigenetic control of MTHFR mutations.
Disclaimer: The information on this site is not intended to be used in place of professional medical advice or treatment, nor is it intended to diagnose, treat, or prevent any disease. Always seek the advice of your physician or other qualified healthcare provider before taking any supplements.